Dexamethasone (DHAP)

CAS No. 50-02-2

Dexamethasone (DHAP)( DHAP )

Catalog No. M14675 CAS No. 50-02-2

Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG 37 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Dexamethasone (DHAP)
  • Note
    Research use only, not for human use.
  • Brief Description
    Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
  • Description
    Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects(In Vitro):MK-3207 (0.3, 0.6, 1.1, 2.3, 4.5, 9.0 nM; 30 min) potently blocks human α-CGRP-stimulated cAMP responses in human CGRP receptor-expressing HEK293 cells.(In Vivo):MK-3207 (0.3, 0.6, 2.1, 9.1, 21.2, 60.6 μg/kg; i.v.; single) inhibits CIDV in rhesus monkeys with EC50 and Emax values of approximately 0.8 nM and 81%.MK-3207 (10 mg/kg; p.o.; single) shows the CSF/plasma ratio is 2 to 3%.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    DHAP
  • Pathway
    Endocrinology/Hormones
  • Target
    Annexin A
  • Recptor
    Annexin A1| Glucocorticoid Receptor| IL receptor| MRP1| iNOS| NR
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    50-02-2
  • Formula Weight
    392.46
  • Molecular Formula
    C22H29FO5
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 6 mg/mL (15.28 mM); DMSO: 79 mg/mL (201.29 mM)
  • SMILES
    O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@]4(C)[C@](C(CO)=O)(O)[C@H](C)C[C@@]4([H])[C@]3([H])CCC2=C1
  • Chemical Name
    (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Warne JP, et al. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1264-73.
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